Recent hypotheses suggest that GIP induces appetite suppression through independent receptors in the brain, mitigates gastrointestinal side effects of GLP-1 action, and prevents desensitization of GLP-1 receptors, thereby acting as a biased GLP-1RA [87]
This limits access for patients who depend on government healthcare services, where the majority of diabetes management occurs
Those with certain medical conditions, pregnant or nursing women, should avoid them
orphan-drug status is not an approval
A vial stored incorrectly for three weeks isn't 70% effective
Human Data: Mixed Early Signals Realworld analyses and observational studies have also hinted that people taking GLP1 drugs for diabetes or weight loss may have a lower risk of dementia, including Alzheimers, compared with users of other diabetes medicines